A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic
spectrum, from animals, plants, fungi, to bacteria. They include numerous complex
monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve
two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2)
metabolism of endogenous and a wide variety of exogenous substrates, such as toxins
and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities
rather than functions, into CYP gene families (>40% homology) and subfamilies (>59%
homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible
for most drug metabolism
Note générale sur le champ d'application :
general or unspecified; prefer specific cytochrome P-450's
Point d'accès autorisé parallèle
Cytochrome P-450 Enzyme System
Identifiants externes
Identifiant MeSH : mesD003577
Utilisation dans FMeSH
Qualificatifs autorisés : IP / IM / PK / BI / PH / TU / BL / CF / CS / DF / CH / DE
/ UR / RE / HI / AN / CL / EC / GE / PD / ST / AD / SD / UL / PO / AE / TO / ME73; CYTOCHROME P-450 OXYGENASE was NM 1977-96
Informations sur la notice
Identifiant de la notice : 040689360
RCR créateur de la notice : 0001
Date de création : 23-09-1998
RCR dernier modificateur de la notice : 4994
Date de dernière modification : 20-03-2024 à 09 h 50