Type III intermediate filament proteins that assemble into neurofilaments, the major
cytoskeletal element in nerve axons and dendrites. They consist of three distinct
polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament
proteins form other cytoskeletal elements such as keratins and lamins. It appears
that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated
by the presence of neurofilament epitopes in the neurofibrillary tangles, as well
as by the severe reduction of the expression of the gene for the light neurofilament
subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol
Sci 1990 Aug;17(3):302)
Note générale sur le champ d'application :
/biosyn /physiol permitted
Point d'accès autorisé parallèle
Neurofilament Proteins
Identifiants externes
Identifiant MeSH : mesD016900
Utilisation dans FMeSH
Qualificatifs autorisés : IP / IM / PK / BI / PH / TU / AG / BL / CF / CS / DF / CH
/ DE / UR / RE / HI / AN / CL / EC / GE / PD / ST / AD / AI / SD / UL / PO / AE /
TO / ME92; was NEUROFILAMENT PROTEINS (NM) 1977-91
Informations sur la notice
Identifiant de la notice : 040816834
RCR créateur de la notice : 0001
Date de création : 23-09-1998
RCR dernier modificateur de la notice : 4994
Date de dernière modification : 20-03-2024 à 10 h 13