An important soluble regulator of the alternative pathway of complement activation
(COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed
by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b
(inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement
factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the
C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT
C3 CONVERTASE, ALTERNATIVE PATHWAY)
Qualificatifs autorisés : IP / IM / PK / BI / PH / TU / AG / CF / CS / DF / CH / DE
/ UR / RE / HI / AN / CL / EC / GE / PD / ST / AD / AI / SD / UL / PO / AE / TO /
ME93; was COMPLEMENT FACTOR H (NM) 1978-92
Informations sur la notice
Identifiant de la notice : 040819957
RCR créateur de la notice : 0001
Date de création : 23-09-1998
RCR dernier modificateur de la notice : 1999
Date de dernière modification : 26-11-2024 à 16 h 08