A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport
organic substrates. Although considered organic anion transporters, a subset of proteins
in this family have also been shown to convey drug resistance to neutral organic drugs.
Their cellular function may have clinical significance for CHEMOTHERAPY in that they
transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class
by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance
(DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the
proteins in this class share little sequence homology to the ATP BINDING CASSETTE
TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins
Qualificatifs autorisés : IP / IM / PK / BI / PH / TU / AG / BL / CF / CS / DF / CH
/ DE / UR / RE / HI / AN / CL / EC / GE / PD / ST / AD / AI / SD / UL / PO / AE /
TO / ME2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN
& MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001
Informations sur la notice
Identifiant de la notice : 064821218
RCR créateur de la notice : 7777
Date de création : 10-08-2002
RCR dernier modificateur de la notice : 1999
Date de dernière modification : 20-03-2024 à 17 h 17