A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains
which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment
domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE
KINASES. The protein plays a role in the host defense response by signaling the activation
of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the
nucleotide oligomerization domain 2 protein have been associated with increased susceptibility
to CROHN DISEASE
Point d'accès autorisé parallèle
Nod2 Signaling Adaptor Protein
Identifiants externes
Identifiant MeSH : mesD053473
Utilisation dans FMeSH
Qualificatifs autorisés : IP / IM / PK / BI / PH / TU / AG / BL / CF / CS / DF / CH
/ DE / UR / RE / HI / AN / CL / EC / GE / PD / ST / AD / AI / SD / UL / PO / AE /
TO / ME2007
Informations sur la notice
Identifiant de la notice : 114610290
RCR créateur de la notice : 0004
Date de création : 05-07-2006
RCR dernier modificateur de la notice : 4994
Date de dernière modification : 20-03-2024 à 10 h 28