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L'auteur rapporte l'observation d'une patiente porteuse d'une forme CRST de la sclérodermie systémique ayant présenté des troubles psychomoteurs ainsi qu'un coma myoclonique en rapport avec une atteinte du système nerveux central par la sclérodermie. A partir de cette observation comparée aux 15 cas publiés dans la littérature ; l'auteur décrit les différentes formes de manifestations neurologiques centrales, les résultats des diverses investigations réalisées, les traitements entrepris ainsi que les évolutions cliniques. Dans la plupart des cas sélectionnés, les atteintes encéphaliques pourraient être dues à une vascularite cérébrale. La relative rareté des atteintes cérébrales semble être liée aux particularités histologiques du tissu cérébral et aux mécanismes physiopathologiques de la sclérodermie dont on ne connaît que les grandes étapes. Au terme de ce travail, l'auteur tente d'établir une possible histoire naturelle de la maladie évoluant en 3 phases afin de pouvoir envisager dans l'avenir des moyens de diagnostic précoce de ces atteintes cérébrales."}],"tag":300},{"ind2":0,"ind1":" ","subfield":[{"code":"b","content":"Thèse d\u2019exercice"},{"code":"c","content":"Médecine générale"},{"code":"e","content":"Nancy 1"},{"code":"d","content":2000}],"tag":328},{"ind2":" ","ind1":" ","subfield":[{"code":7,"content":"ba0yba0"},{"code":"t","content":"Systernic sclerosis and central nervous system involvement, a case report"}],"tag":441},{"ind2":1,"ind1":" ","subfield":[{"code":3,"content":145039013},{"code":7,"content":"ba0yba05"},{"code":"a","content":"Cung"},{"code":"b","content":"Thiên-Aï"},{"code":4,"content":"070"}],"tag":501},{"ind2":1,"ind1":" ","subfield":[{"code":3,"content":"067642586"},{"code":7,"content":"ba0yba05"},{"code":"a","content":"Wahl"},{"code":"b","content":"Denis"},{"code":"f","content":"1959-...."},{"code":4,"content":727}],"tag":501},{"ind2":2,"ind1":0,"subfield":[{"code":3,"content":"059521058"},{"code":7,"content":"ba0yba05"},{"code":"a","content":"Université  de Nancy I"},{"code":"b","content":"Faculté de médecine"},{"code":"c","content":"1970-2011"},{"code":4,"content":295}],"tag":511},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"040746836"},{"code":"a","content":"Neurologie"},{"code":2,"content":"fmesh"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"040747034"},{"code":"a","content":"Neurophysiologie"},{"code":2,"content":"fmesh"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"027240983"},{"code":"a","content":"Neurochirurgie"},{"code":2,"content":"fmesh"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"040777413"},{"code":"a","content":"Sclérodermie localisée"},{"code":2,"content":"fmesh"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"040746828"},{"code":"a","content":"Manifestations neurologiques"},{"code":2,"content":"fmesh"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"040673278"},{"code":"a","content":"Encéphale"},{"code":2,"content":"fmesh"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"027241009"},{"code":"a","content":"Neurologie"},{"code":2,"content":"rameau"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"027240649"},{"code":"a","content":"Neurophysiologie"},{"code":2,"content":"rameau"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"027240983"},{"code":"a","content":"Neurochirurgie"},{"code":2,"content":"rameau"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"031389082"},{"code":"a","content":"Sclérodermie"},{"code":2,"content":"rameau"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"050178679"},{"code":"a","content":"Manifestations neurologiques des maladies"},{"code":2,"content":"rameau"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":3,"content":"033600600"},{"code":"a","content":"Encéphale"},{"code":2,"content":"rameau"}],"tag":606},{"ind2":" ","ind1":" ","subfield":[{"code":7,"content":"ba0yba0"},{"code":3,"content":"027253139"},{"code":"a","content":"Thèses et écrits académiques"},{"code":2,"content":"rameau"}],"tag":608},{"ind2":" ","ind1":" ","subfield":[{"code":7,"content":"ba0yba0"},{"code":3,"content":"040839486"},{"code":"a","content":"Dissertation universitaire"},{"code":2,"content":"fmesh"}],"tag":608},{"ind2":3,"ind1":" ","subfield":[{"code":"a","content":"FR"},{"code":"b","content":"Abes"},{"code":"c","content":20260620},{"code":"g","content":"AFNOR"}],"tag":801}],"controlfield":[{"tag":"001","content":206333773},{"tag":"003","content":"http://www.idref.fr/206333773"},{"tag":"004","content":20171020},{"tag":"005","content":20260620014925},{"tag":"006","content":"0499"},{"tag":"007","content":"0499"},{"tag":"008","content":"Tr2"}]}}