Identifiant pérenne de la notice : 208030042
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Note publique d'information : The targeted addition of ubiquitin to proteins is now known to regulate many cellular
events, with the enzymes involved in protein ubiquitination linked to a variety of
clinical problems, such as cancer, heart disease, and immune dysfunction. In Ubiquitin-Proteasome
Protocols, hands-on leaders in the field, many of whom originally developed the methods
they describe, detail cutting-edge techniques for studying ubiquitin-dependent protein
degradation via the proteasome. The topics covered range broadly from basic biochemistry
to cellular assays to discovery techniques using mass spectrometric analysis. These
biochemical and cellular methods are necessary to explore the ubiquitin-proteasome
system and ubiquitin-proteasome- dependent functions. The protocols follow the successful
Methods in Molecular Biology™ series format, each offering step-by-step laboratory
instructions, an introduction outlining the principle behind the technique, lists
of the necessary equipment and reagents, and tips on troubleshooting and avoiding
known pitfalls. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols
offers novice and experienced bench scientists alike a thorough compendium of readily
reproducible techniques that will accelerate discovery, enhance productivity, and
permit manipulation of the system for varied research purposes
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