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Note publique d'information : The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target
sites for action and these sites are protected by a number of barriers, the most important
being the blood–brain barrier (BBB). Many factors are therefore critical to consider
for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution,
and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma
conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics
are dynamic and often changed by disease/trauma. Knowledge of all these factors and
their interplay in different conditions is of utmost importance for proper CNS drug
development and disease treatment. In recent years much information has become available
for a better understanding of the many factors important for CNS drug delivery and
how they interact to affect drug action. This book describes small and large drug
delivery to the brain with an emphasis on the physiology of the BBB and the principles
and concepts for drug delivery across the BBB and distribution within the brain. It
contains methods descriptions for studying drug delivery, routes and approaches of
administering drugs into the brain, the influence of disease, drug industry perspectives,
and a primer on neuroanatomy and physiological considerations written specifically
for drug delivery scientists. Therewith, it contributes to an in-depth understanding
of the interplay between brain (patho)-physiology and drug characteristics. Furthermore,
the content is designed to be both cutting-edge and educational, so that the book
can be used in high-level training of academic and industry scientists with full references
to original publications
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