cx r22 2 45 212499386 http://www.idref.fr/212499386 20171021 20260701000435.000 0499 0499 Tr2 20171021afrey50 ba0 eng 639-2 2011 k fre 0 # # AFNOR Oeuvre Textuelle ba0yba0 Drug discovery and evaluation, methods in clinical pharmacology, with 153 figures and 95 tables ba0yba0y Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume "Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: "Methods in Clinical Pharmacology". ba0yba0 Drug Discovery and Evaluation: Methods in Clinical Pharmacology ba0yba04 Vogel H.Gerhard 651 ba0yba04 Maas Jochen 651 ba0yba04 Gebauer Alexander 651 035266422 Médicaments Mise au point rameau 027313883 Pharmacologie clinique rameau 027239144 Médicaments 027246647 Pharmacocinétique rameau 143196154 Découverte de médicament fmesh 040696782 Évaluation de médicament 038961520 méthodes fmesh Medicine lc Toxicology lc Pharmacology lc Klinische Pharmakologie Klinisches Experiment swd Biomedicine Pharmacology/Toxicology Pharmacology FR Abes 20260701 AFNOR