Identifiant pérenne de la notice : 212499483
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Note publique d'information : Over the past two decades, tremendous advances have been made in the field of cancer
drug discovery, particularly in the area of molecular and genetic models and technologies,
many of which have been or are beginning to be applied to the drug discovery process
for pancreatic cancer. Drug Discovery in Pancreatic Cancer: Models and Techniques
offers the latest development in the application of those models and technologies
in pancreatic cancer. The authors include experts in their perspective field of research
including basic scientists as well as clinicians who work on the frontline in the
war against pancreatic cancer and have first-hand experience employing these cutting-edge
tools and techniques. The book progresses logically from modeling systems to genomic
profiling, proteomic analysis, and pharmacodynamic assays. It features: • Up-to-date
survey of many cell lines and animal models of pancreatic cancer and their applications
in drug discovery. • Application of fluorescent mouse models in pancreatic cancer
drug discovery. • Utility of cutting-edge genomics, proteomics, epigenomics, and glycomics
methodologies for molecular target identification and validation. • Discussion of
microRNA profiling and high throughput RNAi screening for pancreatic cancer drug discovery.
• Broad screening technologies for proteins and nucleic acids using tissue microarrays
and CGH arrays. • Development of pharmacodynamic endpoint assays for targeted therapeutics.
Comprehensive and practical Drug Discovery in Pancreatic Cancer: Models and Techniques
offers both basic and clinical scientists who are interested in pancreatic cancer
an up-to-date review and assessment of models and technologies being applied in drug
discovery for pancreatic cancer. The true premise of this book is to provide a guide
for drug discovery and evaluation, with consideration of various modeling systems
and the methods for screening/profiling responses to these compounds. It is the Editors
intent to stimulate new thought in this area of research as a means of generating
much improved drug efficacy for greater survival and quality of life for patients
battling pancreatic cancer
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