cx r22 2 45 212500074 http://www.idref.fr/212500074 20171021 20231111014132.000 0499 0499 Tr2 20171021afrey50 ba0 eng 639-2 1993 fre 0 # # AFNOR Oeuvre Textuelle ba0yba0 Drug stereochemistry, analytical methods and pharmacology ba0yba0y "Updated to reflect modern advances in the techniques and methodology of drug stereochemistry, the Third Edition comprehensively presents all aspects of chiral drugs from scientific, academic, governmental, industrial, and clinical points of view. This stand-alone text covers the lifespan of stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drug discovery; A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced during the final stages of the drug development process; The impact of International Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs; A chapter on the legal perspectives of patent issues surrounding racemic switches and the marketing of single enantiomer switches"--Provided by publisher 04068010X Chimie pharmaceutique 040739619 Méthodes fmesh 040783693 Stéréoisomérie fmesh 040742008 Conformation moléculaire fmesh 027815153 Stéréochimie rameau 028885171 Stéréoisomères rameau 029408873 Médicaments Relations structure-activité rameau 027797996 Chimie pharmaceutique rameau Stereoisomers mesh Stereoisomerism mesh Chemistry, Pharmaceutical methods mesh Molecular Conformation mesh Chiral drugs lc Pharmaceutical chemistry lc Stereochemistry lc FR Abes 20231111 AFNOR