Identifiant pérenne de la notice : 218863187
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Note publique d'information : Patch Clamp Methods and Protocols surveys the typical patch clamp applications and
advises scientists on identifying problems and selecting the best technique in each
instance. The experiments described require a basic level of electrophysiological
training and aid the researcher in pursuing new areas of electrophysiology and using
the patch clamp technique effectively. Patch Clamp Methods and Protocols is divided
into three sections that cover the major areas of patch clamp application: Pharmacology,
Physiology, and Biophysics. The first section provides examples and step by step instructions
on how to use whole-cell and single-channel patch clamp methods for testing drugs
in industrial settings. The second section provides a wide selection of patch clamp
applications in physiological studies. The last part focuses on the biophysical applications
of the patch clamp method using single channel recordings or statistical analysis
of whole-cell currents in order to obtain parameters that describe ion channel properties
or transmitter release. Individual techniques are explored within the area that they
are applied most often. Researchers will find Patch Clamp Methods and Protocols to
be an invaluable aid in the design and execution of a wide variety of patch clamp
experiments, both on their own and in conjunction with other state-of-the-art methodologies
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