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Note publique d'information : This volume provides in-depth reviews of model systems that exemplify the arms race
in host-pathogen interactions. Somatic adaptations are responsible for the individualization
of biological responses to the environment, and the continual struggle between host
immune systems and invading pathogens has given rise to corresponding processes that
produce molecular variation. Whether in mollusks or human beings, various host somatic
mechanisms have evolved independently, providing responses to counter rapidly-changing
pathogens. The pathways they utilize can include non-heritable changes involving RNA
and post-translational modifications, or changes that produce somatic DNA recombination
and mutation. For infectious organisms such as protozoans and flatworms, antigenic
variation is central to their survival strategy. Evolving the ability to evade the
host immune system not only increases their chances of survival but is also necessary
for successful re-infection within the host population
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