cx r22 2 45 218865384 http://www.idref.fr/218865384 20171022 20251210150551.000 0499 0499 Tr2 20171022afrey50 ba0 eng 639-2 2013 k fre 0 # # AFNOR Oeuvre Textuelle ba0yba0 Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism ba0yba0y Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts Medicine lc Immunology lc Microbiology lc Drug interactions lc Microbial genetics lc Molecular biology lc Medical microbiology lc Drug resistance lc Microbial genomics lc 027658236 Mycobacterium tuberculosis rameau 040743969 Mycobacterium tuberculosis 038961512 métabolisme fmesh 040743969 Mycobacterium tuberculosis 03896158X pathogénicité fmesh 123503795 Interactions hôte-pathogène fmesh Biomedicine Medical Microbiology Immunology Molecular Medicine Drug Resistance Microbial Genetics and Genomics FR Abes 20251210 AFNOR