{"record":{"leader":"cx  r22     2  45","datafield":[{"ind2":" ","ind1":" ","subfield":{"code":"a","content":"20221214afrey50      ba0"},"tag":100},{"ind2":" ","ind1":" ","subfield":[{"code":"a","content":"fre"},{"code":2,"content":"639-2"}],"tag":101},{"ind2":" ","ind1":" ","subfield":{"code":"a","content":2022},"tag":103},{"ind2":" ","ind1":" ","subfield":[{"code":"a","content":"k"},{"code":"f","content":"fre"}],"tag":104},{"ind2":" ","ind1":" ","subfield":[{"code":"a","content":0},{"code":"b","content":"#"},{"code":"c","content":"#"}],"tag":106},{"ind2":" ","ind1":" ","subfield":{"code":"a","content":"AFNOR"},"tag":152},{"ind2":" ","ind1":" ","subfield":{"code":"a","content":"Oeuvre Textuelle"},"tag":189},{"ind2":" ","ind1":" ","subfield":[{"code":7,"content":"ba0yba0"},{"code":"t","content":"Diagnostic immunologique et intérêt des nouveaux auto-anticorps dans la sclérodermie systémique"}],"tag":241},{"ind2":" ","ind1":" ","subfield":[{"code":7,"content":"ba0yba0y"},{"code":"a","content":"La sclérodermie systémique est une maladie auto-immune qui présente trois principales caractéristiques qui sont la fibrose tissulaire, la microvasculopathie et l\u2019auto-immunité. Elle demeure une affection rare, dont l\u2019étiologie n\u2019est pas encore connue et qui reste à ce jour incurable. Elle se présente comme une maladie hétérogène avec des phénotypes cliniques très variables d\u2019un patient à l\u2019autre. Le type d'auto-anticorps associés est souvent prédictif de l\u2019atteinte clinique, de la gravité et du pronostic de la maladie. Une connaissance approfondie des biomarqueurs immunologiques et de leurs caractéristiques cliniques permettrait une meilleure prise en charge des patients dès leur diagnostic. Des nouveaux auto-anticorps, récemment décrits, apparaissent prometteurs. Ils pourraient ainsi permettre d'élargir le panel d\u2019auto-anticorps disponibles dans la sclérodermie systémique."}],"tag":300},{"ind2":" ","ind1":" ","subfield":[{"code":7,"content":"ba0yba0y"},{"code":"a","content":"Systemic sclerosis is an autoimmune disease with three main characteristics: tissue fibrosis, microvasculopathy and autoimmunity. 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