Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic
neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein
proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA
NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are
associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON
DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent
examples of synucleinopathy
Qualificatifs autorisés : DI / PS / IM / MI / DG / PP / RH / EN / ET / MO / EP / BL
/ CF / CI / CN / DH / DT / TH / PX / UR / VI / VE / HI / CL / EC / EM / GE / NU /
RT / EH / PC / PA / ME / CO / SU2020
Informations sur la notice
Identifiant de la notice : 27633177X
RCR créateur de la notice : 4994
Date de création : 12-03-2024
RCR dernier modificateur de la notice : 1999
Date de dernière modification : 20-03-2024 à 17 h 08