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Note publique d'information : Epigenetics is a rapidly expanding field in medical and biological research which
concerns heritable traits that are not attributable to changes in the DNA sequence.
Epigenetic mechanisms play key roles in many biological processes, and it has become
clear that their disruption can gives rise to diverse pathologies in humans. Edited
by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics
and Human Health’ series discusses the role of epigenetics in human reproduction.
The book presents epigenetic transitions that are important at defined stages of gametogenesis
and during meiosis. Several of the sixteen chapters written by experts in the field
cover fundamental concepts discovered through cellular and biochemical work and from
research on animal models. In other chapters, key examples are provided of how disruption
of these mechanisms affects germ cell development and fertility, and contributes to
the germinal cancers. Finally, the book discusses how in vitro manipulation and culture
in assisted reproduction can epigenetically perturb germ cells, and how this can trigger
disease phenotypes in the next generation. Conceived towards advanced students, medical
professionals and research scientists, this is the first comprehensive textbook on
this topic that will serve as a valuable reference during the years to come.
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