Identifiant pérenne de la notice : 212500074
Notice de type
Notice de regroupement
Note publique d'information : "Updated to reflect modern advances in the techniques and methodology of drug stereochemistry,
the Third Edition comprehensively presents all aspects of chiral drugs from scientific,
academic, governmental, industrial, and clinical points of view. This stand-alone
text covers the lifespan of stereochemistry, from its early history, including an
overview of terms and concepts, to the current drug development process, legal and
regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition
include: The use of enzymes in the synthesis and resolution of enantiometrically pure
compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption,
Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drug discovery;
A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced
during the final stages of the drug development process; The impact of International
Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The
concept of molecular chiral recognition and how it affects the separation and behavior
of stereochemically pure drugs; A chapter on the legal perspectives of patent issues
surrounding racemic switches and the marketing of single enantiomer switches"--Provided
by publisher
paprika.idref.fr
data.idref.fr
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