Identifiant pérenne de la notice : 218865384
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Note publique d'information : Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing
the death of approximately 1.5 million people annually. A major problem in the fight
against tuberculosis is the emergence of strains that have acquired resistance to
all available antibiotics. One key to the success of M. tuberculosis as a pathogen
is its ability to circumvent host immune responses at different levels. This is not
only a result of the special makeup of M. tuberculosis in terms of genetic diversity
and DNA metabolism and its possession of specialized secretion systems, but also of
its ability to hijack the host’s innate immune defence mechanisms. In this volume,
researchers from different disciplines provide a topical overview of the diverse mechanisms
that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic
and molecular makeup, as well as the complex strategies these bacteria utilize to
escape immune destruction within infected hosts
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